CAS 68-12-2

N,N-dimethylformamide is an natural compound with the components C3H7NO and is a colorless obvious liquid. It is no longer solely a chemical uncooked fabric with a large vary of uses, however additionally an tremendous solvent with a broad vary of uses. It can be arbitrarily blended with water and most natural solvents, and has exact solubility for a range of organic compounds and inorganic compounds
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It is no longer solely a chemical uncooked cloth with a huge vary of uses, however additionally an high-quality solvent with a huge vary of uses.
Pharmacological research
Metabolism: After DMF is absorbed by means of a number ways, it is usually metabolized by way of the liver and excreted quickly, the important goal organ is the liver, and the kidney additionally has sure damage. It is normally demethylated by using the blended purposeful oxidase of microsomal microsomes in the liver, and a methyl crew is removed, and the metabolites are methylformamide and formamide, which are metabolized rapidly; Formamide stays in the blood for a barely longer duration of time, and is metabolized to formic acid and ammonia excretion. Part of the dimethylformamide is excreted in its unique structure from urine and exhalation.
Health hazards: anxious impact on eyes, pores and skin and respiratory tract. Vapor can reason moderate to reasonable infection of the eyes and higher respiratory tract. Polluting the pores and skin can reason slight and extreme burns, pores and skin wrinkling, white complexion, accompanied by way of burning pain, extreme instances can make the pores and skin swollen, extreme burning pain. Contaminated eyes motive burning pain, tearing, conjunctival hyperemia; Severe instances can motive corneal necrosis.
Gastrointestinal symptoms: sufferers regularly have loss of appetite, nausea, vomiting, belly pain and constipation, and a few instances have center and top stomach pain.
Liver: Liver harm is regularly outstanding in acute poisoning, patients have apparent fatigue, proper top quadrant distention, pain, discomfort, jaundice, liver regularly enlarged, tenderness, activities liver feature checks exhibit abnormalities, amongst which serum aminotransferase elevation is greater obvious. The lesions are typically now not serious, and can be progressively decreased with treatment, and the circumstance can be wholly recovered inside a few weeks.