N,N-Dimethylformamide

N,N-dimethylformamide is an organic compound with the formula C3H7NO and is a colorless transparent liquid. It is not only a chemical raw material with a wide range of uses, but also an excellent solvent with a wide range of uses. It can be arbitrarily mixed with water and most organic solvents, and has good solubility for a variety of organic compounds and inorganic compounds

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It is not only a chemical raw material with a wide range of uses, but also an excellent solvent with a wide range of uses.

Pharmacological research

Metabolism: After DMF is absorbed by various ways, it is mainly metabolized by the liver and excreted quickly, the main target organ is the liver, and the kidney also has certain damage. It is mainly demethylated by the mixed functional oxidase of microsomal microsomes in the liver, and a methyl group is removed, and the metabolites are methylformamide and formamide, which are metabolized rapidly; Formamide remains in the blood for a slightly longer period of time, and is metabolized to formic acid and ammonia excretion. Part of the dimethylformamide is excreted in its original form from urine and exhalation.

Health hazards: irritating effect on eyes, skin and respiratory tract. Vapor can cause mild to moderate irritation of the eyes and upper respiratory tract. Polluting the skin can cause mild and severe burns, skin wrinkling, white complexion, accompanied by burning pain, severe cases can make the skin swollen, severe burning pain. Contaminated eyes cause burning pain, tearing, conjunctival hyperemia; Severe cases can cause corneal necrosis.

Gastrointestinal symptoms: patients often have loss of appetite, nausea, vomiting, abdominal discomfort and constipation, and a few cases have middle and upper abdominal pain.

Liver: Liver damage is often prominent in acute poisoning, patients have obvious fatigue, right upper quadrant distention, pain, discomfort, jaundice, liver gradually enlarged, tenderness, routine liver function tests show abnormalities, among which serum aminotransferase elevation is more obvious. The lesions are generally not serious, and can be gradually reduced with treatment, and the condition can be fully recovered within a few weeks.