CAS 1622-61-3

Clonazepam , with the system C15H10ClN3O3 , is a benzodiazepine tranquilizer. Clinically, it is commonly used for: (1) therapy of epilepsy and convulsions, which are advantageous for all kinds of epilepsy, in particular for small seizures and myoclonic seizures. Intravenous therapy of popularity epilepticus. (2) Treatment of anxiousness and insomnia. (3) It is additionally high quality for choreas. It additionally has a sure impact on drug-induced hyperactivity, continual more than one convulsions, stiff man syndrome, and a range of kinds of neuralgia.
The impact is comparable to diazepam and nitrazepam. However, the anticonvulsant impact is 5 instances improved than the first two, and the impact is rapid. Similar to the central inhibitory impact of different BDZ drugs, due to the acceleration of chloride inflow of nerve cells, the cells are hyperpolarized and the excitability of nerve cells is reduced. At the equal time, it additionally has a sure impact on glutamate decarboxylase, so it has a broad-spectrum anti-epileptic effect. This product additionally has anxiolytic, hypnotic and central muscle leisure effects.
Oral absorption is good, and the blood attention peaks in two to four hours. The plasma half-life is 20 to 40 hours. It is noticeably fat-soluble and without difficulty passes via the blood-brain barrier. It takes impact after 30 to 60 minutes of oral administration, and the impact can final for 6 to eight hours. Almost all is metabolized in the liver, by and large through the CYP3A enzyme. Metabolites are excreted in the urine in free or conjugated form, and solely a very small quantity is excreted in the shape of the authentic drug.