2,4-Dichloro-5-fluorobenzoyl chloride

Boiling Point: 143-144 °C35 mm Hg(lit.)

Density: 1.568 g/mL at 25 °C(lit.)

Refractive index n20/D 1.572(lit.)

Flash point > 230 °F

Specific gravity 1.568

Sensitivity: Moisture sensitivity

BRN4989077

CAS DataBase Reference: 86393-34-2

use

2,4-Dichloro-5-fluorobenzoyl chloride is the main raw material for the preparation of third-generation quinolones such as trifluoroperidinol, trifluoroguabutenyl, pentafluridol and synthetic broad-spectrum antibiotics such as ciprofloxacin, and can also be used for pesticides, insecticides and ovicides, as well as the identification of plastics and resins.

synthesis

A synthesis method of 2,4-dichloro-5-fluorobenzoyl chloride comprises: 2,4-dichlorofluorobenzene, carbon dioxide and carbon tetrachloride are prepared under the action of cationic resin catalyst. The dosage of the cationic resin catalyst is 1%~10% of the mass of 2,4-dichlorofluorobenzene, and the preparation method of the cationic resin catalyst comprises: the cationic resin is first treated with 1mol/L of sodium hydroxide, then washed with hydrochloric acid, washed with water to neutral and then immersed in 0.5mol/LFeCl3 solution and stirred for 5~10 hours, and then HF is added to pH of 2~3; After the reaction system is aged at -3~-6 °C for 20~30h, it is filtered and washed, and then the filter cake is dried at 70~90 °C to obtain the cationic resin catalyst.