CAS 9067-32-7

Sodium hyaluronate, chemical formula (C14H20NO11Na)n, is an inherent component of the human body, is a glucuronic acid, no specific species, it is widely present in placenta, amniotic fluid, lens, articular cartilage, skin dermis and other tissues and organs. It is distributed in the cytoplasm and interstitium, which lubricates and nourishes the cells contained in it and the cellular organs themselves.

It also provides a microenvironment for cell metabolism. It is a gel made from a natural "hyaluronic acid" in combination with other drugs that promote cell regeneration and wrinkle reduction, and is administered by injection.

Moisturizing effect is the most important role of sodium hyaluronate in cosmetics, and compared with other moisturizers, the relative humidity of the surrounding environment has less influence on its moisturizing property.

Enhance efficacy

HA is a major component of connective tissue such as human interstitium, vitreous body of eye and synovial fluid of joint. It has the properties of retaining water, maintaining extracellular space, regulating osmotic pressure, lubricating and promoting cell repair in the body. As a carrier of ophthalmic drugs, it prolongs the retention time of drugs on the eye surface by increasing the viscosity of eye drops, improves the bioavailability of drugs, and reduces the irritation of drugs on the eye.

Adjuvant therapy: It can be directly injected into the joint cavity as a lubricant for the treatment of arthritis [1]. The moisturizing function of sodium hyaluronate in skin tissue is one of its most important physiological functions, and sufficient moisture makes the skin smooth and delicate. HA has the highest hygroscopic capacity under low relative humidity (33%) and the lowest hygroscopic capacity under high relative humidity (75%), which is suitable for the skin's moisturizing needs for cosmetics in different seasons and different environmental humidity, and does not have the feeling of being fatty and blocking pores.

Wrinkle resistance

The moisture level of the skin is closely related to the content of hyaluronic acid. With the increase of age, the content of hyaluronic acid in the skin decreases, which weakens the water retention function of the skin and produces wrinkles. Sodium hyaluronate aqueous solution has strong viscoelasticity and lubricity. When applied to the skin surface, it can form a moisturizing breathable film to keep the skin moist and shiny. Small molecules of hyaluronic acid can penetrate into the dermis, promote blood microcirculation, is conducive to the absorption of nutrients in the skin, and play a health care role in beauty and anti-wrinkle.

Film formation and lubricity belong to high polymer, which has obvious lubrication and good hand feel when applied. Large molecules form a breathable film on the skin surface, making the skin smooth and moist, blocking the invasion of foreign bacteria and dust. Small molecules of sodium hyaluronate can penetrate into the dermis, slightly expand capillaries, increase blood circulation, improve intermediate metabolism, and promote skin nutrient absorption. Achieve lubrication, full effect.

Sunscreen and skin damage repair function on the skin surface can eliminate the reactive oxygen species generated by ultraviolet radiation in the sun, protect the skin from ultraviolet damage, and also promote the regeneration of the skin at the injured site by promoting the proliferation and differentiation of epidermal cells.

Moisturizing effect

Experiments showed that compared with these humectants, sodium hyaluronate had the highest hygroscopic capacity at low relative humidity (33%) and the lowest hygroscopic capacity at high relative humidity (75%). This unique nature is adapted to the skin in different seasons, different environmental humidity, such as dry winter and wet summer, the moisturizing effect of cosmetics requirements. The moisture retention of sodium hyaluronate is related to its quality, the higher the quality, the better the moisture retention. Sodium hyaluronate is rarely used as a humectant alone, and is often used in combination with other humectants.