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1. Heparin was originally extracted from the liver, and is now mostly extracted from the intestinal mucosa of pigs, sheep, cattle and other animals, and can be extracted from the lungs and liver. Put the fresh intestinal mucosa into the reaction pot, add sodium chloride at 3%, and adjust the pH to 9.5 with 40% sodium hydroxide. Gradually heat up to 60-65 ° C within half an hour, continue to hold heat and stir for 2h, then heat up to 95 ° C, maintain for 10min, cool to below 50 ° C and filter.
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Storage Conditions/Storage methods:Seal away from light and store in a cool place.Stability related:Other information:1. Properties: White or white powder. Almost odorless, tasteless and hygroscopic.2. Solubility: soluble in water and salt water, insoluble in ethanol, acetone, benzene, chloroform and ether. The pH of 1% aqueous solution is 6.0~7.5.Heparin was originally extracted from the liver, and is now mostly extracted from the intestinal mucosa of pigs, sheep, cattle and other animals, and can be extracted from the lungs and liver.
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Sulfadiazine is an organic compound with a molecular formula of C10H10N4O2S, white or off-white crystals or powders, odorless, tasteless, and gradually darkened when exposed to light. Almost insoluble in water, soluble in boiling water (1:60), slightly soluble in ethanol and acetone, insoluble in chloroform and ether, soluble in dilute hydrochloric acid, sodium hydroxide solution or ammonia solution. Melting point 252~256 °C (simultaneous decomposition). Its sodium salt is white crystalline powder, odorless, slightly bitter taste. Gradient brownish upon light.
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Character description: colorless obvious liquid. Melting factor -90.2C, boiling factor 117.7 °C, relative density 0.8098 (20/4C), refractive index 1.3993, flash factor 35.35.5 °C, spontaneous ignition factor 365 °C. The solubility in water at 20 °C is 7.7% (mass), and the solubility of water in n-butanol is 20.1% (mass). Miscible with ethanol, ethyl and different natural solvents. Vapor varieties an explosive combination with air, with an explosion restrict of 1.45-11.25 (volume).
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Basic informationChinese name: AtecaineChinese aliases: aceclofenac impurity H; Methyl 4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylate; [1]English name: Articaine;Methyl (4-methyl-3-(2-(propylamino)propionamido)-2-thiophencarboxylat); 3-(N-propyl-2-amino-propionylamino)-2-carbomethoxy-4-methylthiophene; 4-Methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylic acid,methyl ester; Articaina [INN-Spanish]; Carticaine;Aticaine compound is a white crystalline powder with the formula 4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylate.
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Uroptrazine, also known as hexamethylenetetramine, has the formula C6H12N4 and is an organic compound.It is listed in the "List of Hazardous Chemicals Prone to Explosion" [1] and controlled in accordance with the "Measures for the Safety Management of Hazardous Chemicals that Can Be Made into Explosives"Toxicological dataAcute toxicity: LD50: 9200mg/kg (rat venous); 569mg/kg (mouse by mouth).[3] Use of methenamineUsed as a curing agent for resins and plastics, catalyst and foaming agent for amino plastics, accelerator for rubber vulcanization (accelerator H), anti-shri
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Materialized propertiesDensity:1.52±0.1 g/cm3(Predicted)Boiling point:545.3±50.0 °C(Predicted)PSA:80.65000logP:2.52900Acidity coefficient (PKA):11.15±0.70(Predicted)English alias(S)-Methyl 3-(7-bromo-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanoate1H-1,4-Benzodiazepine-3-propanoic acid, 7-bromo-2,3-dihydro-2-oxo-5-(2- pyridinyl)-, methyl ester, (3S)-(3S)-(7-BroMo-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionic acid Methyl esterMethyl 3-[(3S)-7-bromo-2-oxo-5-(2- pyridinyl)-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanoateCAS308242-23-1InchiInC
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Clonazepam , with the formula C15H10ClN3O3 , is a benzodiazepine tranquilizer. Clinically, it is mainly used for: (1) treatment of epilepsy and convulsions, which are effective for all types of epilepsy, especially for small seizures and myoclonic seizures. Intravenous treatment of status epilepticus. (2) Treatment of anxiety and insomnia. (3) It is also effective for choreas. It also has a certain effect on drug-induced hyperactivity, chronic multiple convulsions, stiff man syndrome, and various types of neuralgia.The effect is similar to diazepam and nitrazepam.
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CAS:21739-92-4Product Category: Chemical Intermediates - Other Intermediates Cas Number: 21739-92-4Product Specifications: 99% Packing: 25 kg Brand: Runde Detailed Description:5-Bromo-2-chlorobenzoic acidChinese synonyms: 2-Chloro-5-bromobenzoic acid; 5-Bromo-2-chlorobenzoic acid; 5-Bromo-2-chlorobenzoic acid; 5-BroMo-2-chlorobenzoic acid, 98+%; 5-Bromo-2-chlorobenzoic acid; 2-Chloro-5-bromobenzoic acid, 99.86%; 5-Bromo-2-chlorobenzoic acid/2-chloro-5-bromobenzoic acid; 5-BroMo-2-chlorobenzoic acid, 98+%Name: 5-Bromo-2-chlorobenzoic acidEnglish synonyms:Benzoic acid, 5-bromo-2-chloro-; 2-CHLOR
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Appearance: Yellow needle-like crystals.
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In 1929, Daim located that there are two types of diet K in nature, K1 and K2, each of which are naphthoquinone compounds. Vitamin K2 is a naturally going on nutrition containing the simple shape of menaquinone and has anti-bleeding effects, yellow crystal or oily liquid at room temperature, insoluble in water, soluble in natural solvents and vegetable oils, heat-resistant, however effortless to be damaged via light.
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Phentermine (Phentermine), an organic compound with a molecular formula of C10H15N, is clinically used as an anorexia (diet drug) for the short-term treatment of moderate to severe obesity, and is listed as a Class II psychotropic drug controlBasic informationChinese name: phentermineEnglish name: phentermineMolecular Formula: C10H15NMolecular Weight: 149.233CAS number: 122-09-8EINECS number: 204-522-1PSA:26.02000LogP:2.66670Physical and chemical propertiesDensity: 0.938 g/cm3Boiling point: 206ºCFlash point: 93.1ºCRefractive index: 1.523Vapour pressure: 0.243mmHg at 25°C Molecular structu
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Appearance characteristicsThis product is white crystal, m.p.138~140 °C, insoluble in water, soluble in alcohol, ether, etc.Melting Point: 134-136 °C (lit.)Melting Point: 134-136 °C(lit.)Boiling Point: 272.96°C (rough estimate)Density 1.35Density 1.35refractive index1.4500 (estimate)Flash point 250 °CFlash point 250 °CStorage conditions: 2-8 °CStorage conditionsStore at RT.Solubility H2O: 10 mg/mL at 37 °CSolubility in water Solubility 10 mg/mLat 37 °CMorphological crystallineThe color is whiteAcidity coefficient (pKa): 3.5 (at 25°C)Water solubility: 3.3 g/L (20 ºC)Merck14,851BRN779271Exposure
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TriacetateGlyceryl triacetate is an organic compound with a C9H14O6 molecular formula, colorless and odorless oily liquid, miscible with ethanol, ether, chloroform and benzene, slightly soluble in water and carbon disulfide. Used as cigarette filter binder and fragrance fixative, solvent, toughening agent. And can be used in cosmetics, casting, medicine, dyes and other industries.
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 Experimental characteristicsLogP2.47600PSA55.98000Melting point 153-155°CDensity 1.215 Calculate the characteristicsExact molecular weight 198.07900Number of hydrogen bonded donors 1Number of hydrogen bond receptors 3Number of rotatable chemical bonds 2Number of heavy atoms 15Complexity 230Number of isotope atoms 0Determine the number of atomic stereoscopic centers 0The number of atomic stereoscopic centers is uncertain 0Determine the number of chemical bond stereotactic centers 0The number of chemical bond stereotactic centers is uncertain 0Number of covalent bond units 1Hydrophobi
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Chinese aliaso-Aminobenzonitrile 2-aminobenzonitrile 2-cyanoaniline-o-cyanoaniline 2-aminobenzonitrile 50G2-aminobenzonitrile 2-aminobenzonitrile 2-amino-benzonitrile 2-aminophenylhydrazine 2-aminobenzonitrileEnglish aliasO-AMINOBENZONITRILE2-Aminobenzonitrile, (AnthranilonitrileO-CYANOANILINE2-amino-benzonitrilBenzonitrile,  o-amino-Aminobenzonitrile2-Cyano-1-aminobenzene2-amino-benzonitrile1-amino-2-cyanobenzene2-CyanoanilineEINECS 217-549-92- cyano-anilineAnthranilonitrileortho-cyanoaniline2-AminobenzolcarbonitrilBenzonitrile, 2-amino-amino benzonitrileBenzonitrile,2-amino2-Amino Benzo
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Purpose 1It can be widely used in food, cosmetics, dietary supplements and other industries.Purpose 2Coenzymes. It is also an important antioxidant and immune booster. It is used for the adjuvant treatment of congestive heart failure, arrhythmia, sinus tachycardia, premature contractions, hypertension and cancer, and for the comprehensive treatment of acute and chronic viral hepatitis and subacute liver necrosis. In addition, it is also used for primary and secondary hyperaldosteronism, cerebrovascular disorders and hemorrhagic shock.
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An natural compound, colorless obvious liquid with a relative density of 0.971, soluble in natural solvents such as alcohols, ethers and ethyl acetate.
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Chinese name: tripropylene glycolEnglish name: Tripropylene glycolAlias: H[OC2H3(CH3)]3OHEnglish synonyms: Tripropylenglycol; TRI(PROPYLENE GLYCOL); Tripropyleneglycol,90%; Tripropylene glycol 97%; Tripropylene Glycol Twothe three glycol reduction; Tripropylene Glycol(isomer mix.); 1,1'-(Propylenedioxy)dipropan-2-ol; tripropyleneglycol,mixtureofisomers; [(methylethylene)bis(oxy)]dipropanolChinese Name: Tripropylene glycolChinese synonyms: tripropylene; Diols; Dipropylene glycol; Tris(propylene glycol); trimer 1,2-propanediol; Tripropylene glycol (mixture of isomers); Dipropylene glycol (mi
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1.3-Butanediol is an organic compound with a molecular formula of C4H10O2, mainly used in the preparation of polyester resin, polyurethane resin, plasticizer, etc., and also used as a humidifier and softener for textiles, paper and tobacco.Chinese Name: 1,3-ButanediolChinese aliases: 1,3-Dihydroxybutane; (±)-1,3-ButanediolEnglish alias: Butanediol; butane-1,3-diol; (3S)-butane-1,3-diol; (3R)-butane-1,3-diolCAS:107-88-0EINECS:203-529-7FEMA registration number: 2842Physical and chemical indicatorsAppearance: colorless, viscous liquid.Melting point (°C): <-54Boiling point (°C): 207°C at 760 mm
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Chinese aliasBromazepam Impurity A Bromazepam Impurity A(EP) Standard 2-Amino-5-bromophenyl-2-pyridylmethanone 2-(2-amino-5-bromobenzoyl)pyridineEnglish alias2-(5-Bromo-2-aminobenzoyl)pyridine(2-Amino-5-bromophenyl)-2-pyridinylmethanone2-(2-Amino-5-bromobenzoyl)pyridineKetone, 2-amino-5-bromophenyl 2-pyridyl2-Amino-5-bromophenyl-2-pyridylmethanone2-Amino-5-bromophenyl 2-pyridyl ketone(2-amino-5-bromophenyl)-pyridin-2-ylmethanone2-(2-AMINO-5-BROMOBENZOYL)  PYRIDINE4-bromo-2-[(pyridin-2-yl)carbonyl]anilineMethanone, (2-amino-5-bromophenyl)-2-pyridinyl-(2-Amino-5-bromophenyl)(2-pyridinyl)met
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N,N-dimethylformamide is an organic compound with the formula C3H7NO and is a colorless transparent liquid. It is not only a chemical raw material with a wide range of uses, but also an excellent solvent with a wide range of uses.
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Pharmacology and toxicologyWhen the plasma awareness exceeds 5 μg·mL-1, convulsions can occur, and at low doses, it can promote the outflow of K+ in myocardial cells, minimize the auto-discipline of the myocardium, and have anti-ventricular arrhythmic effect; At therapeutic doses, there is no full-size impact on the electrical endeavor of cardiomyocytes, atrioventricular conduction and contraction of myocardium; Further enlarge in blood awareness can reason slowing of cardiac conduction velocity, atrioventricular block,
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Cyclohexanone is an organic compound with the formula C6H10O , a saturated cyclic ketone with carbonyl carbon atoms included in a six-membered ring. Colorless transparent liquid with earthy smell, with mint smell when containing trace amounts of phenol. Impurities are light yellow, which develop color with the formation of impurities during storage time, and are water-white to gray-yellow, with a strong pungent odor. Mixed with air, the explosive pole is the same as open-chain saturated ketone.
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Medicine intermediate refers to a compound generated as an intermediate step in the process of synthetic drugs. It has high purity and activity, which can synthesize target drugs through further chemical reactions. Medicine intermediates are widely used in the pharmaceutical industry, covering multiple fields. The classification of pharmaceutical intermediates and its application areas will be introduced below.1. Carboxylic acid intermediate:The intermediate of the carboxylic acid refers to the compound of the carboxylic acid group, and the common ones are benzoic acid and propylic acid.
May 13, 2020. Pharmaceutical intermediate body fluorine customized. Pharmaceutical fluorine: colorless liquid. The melting point -42 ℃. Boiling point 85 ° C. Refractive index (ND20) 1.4650. Relators (D420) 1.024. Insuvenate in water and mixes with ethanol, ether, acetone, and benzene. Apineine reacts through Schiemann (G. Schiemann).Ah. After the aniline was descended to -8 ° C after 31%hydrochloride, and the sodium nitrite solution was nitroded.
April 23, 2020. Customized in the middle of Shandong Pharmaceutical. The so -called Shandong pharmaceutical intermediate is actually some chemical raw materials or chemical products for drug synthesis process. This kind of chemical product does not require the production license of drugs. It can be produced in ordinary chemical plants. As long as it reaches some levels, it can be used for the synthesis of drugs.There are more than 2,000 raw materials and intermediates that need to be matched with chemicals each year, with more than 2.5 million tons.
I. Overview of chemical and pharmaceutical intermediatesChemical pharmaceutical intermediates are a very important part of the pharmaceutical industry, referring to raw materials or semi-finished products in the pharmaceutical industry. These substances undergo a series of chemical reactions to eventually form pharmaceutical products. These chemicals usually exist in liquid or solid form and belong to various types of organic compounds such as acids, alcohols, carboxylic acids, phenols, cork and so on.
Shandong is one of the important pharmaceutical production bases in the country, and the production production is relatively concentrated. The treatment of Shandong Pharmaceutical Intermediate waste is essential for protecting the environment, human health, and sustainable enterprise. This article will discuss how to properly handle waste in the production of Shandong pharmaceutical intermediates.First, reasonable classification and storage wasteReasonable classification and storage waste are the first step in waste treatment.
Intermediate production of chemical medicine is a work involving a large number of chemicals. If it is not managed and controlled correctly, it may bring serious risks and pollution to the environment. In order to reduce environmental risks in the production of chemical medicine, we need to improve and control from the following aspects.First, establish a scientific and standardized production process. The production of chemical medicine needs to go through multiple steps and reactions. Each step needs to carefully evaluate and formulate corresponding operating procedures.