Purpose 1Biochemical studies, adrenocorticosteroid drugs.Purpose 2Glucocorticoids have four major effects: anti-inflammatory, anti-allergic, anti-toxin, and anti-shock.Purpose 3The adrenal cortex secretes the main glucocorticoid, which has three times the anti-inflammatory power of corticosterone.Refer to quality standardsThe content is 96%-104%, mp212-220°C, the specific rotation [α] 20D+161°-+169°, the absorbance coefficient (A) is 428-450, and the content of impurities such as loss on drying and burning residue is detected.
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Hydrazine hydrate, also known as hydrazine hydrate, is a colorless and transparent oily liquid with a light ammonia smell, smoke in humid air, and is highly alkaline and hygroscopic.
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Chemical and physical properties of benzophenone hydrazoneDensity 1.1±0.1 g/cm3Boiling point 328.0±11.0 °C at 760 mmHgmelting point 95-98 °C(lit.)Molecular Formula C13H12N2Molecular weight 196.248Flash point 152.1±19.3 °CExact mass 196.100052PSA 38.38000LogP 2.79Appearance: White crystalline powderVapor pressure 0.0±0.7 mmHg at 25°CThe refractive index is 1.584Storage conditionsProtect from light, cool and dry place, sealed and storedstabilityStable at room temperature and pressure, white crystalline powder.MolecularMolecular property data:1. Molar refractive index: 62.322.
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Chinese name: 1-[[2-(4-chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride Chinese synonymous with green casserin intermediate; Lorcaserin intermediate 2; Lorcaserin Impurity B; 1-[[2-(4-chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride; Lorcaserin hydrochloride intermediate 2; 2-Chloro-N-(4-chlorophenethyl)propan-1-amine chloride; Lorcaserin impurity B (EP); Chlorocasein Impurity B English name 1-[[2-(4-Chlorophenyl)ethyl]amino]-2-chloropropane English synonym 1-[[2-(4-Chlorophenyl)ethyl]amino]-2-chloropropane; 1-[[2-(4-Chlorophenyl)ethyl]amino]-2-chloropropaneHydrochloride; Benzene
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Appearance: Yellow needle-like crystals.
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Chinese Name: Thiopidine trioxide Chinese synonyms: compounds of thiopidine trioxide; sulfur trioxide-pyridine complex; Pyridine sulfur trioxide; Thiopidine trioxide; Thiopidine trioxide complex; Synthesis of thiophorine trioxide; Sulfur trioxide yridine complex; Sulfurtrioxypyridine complex [2]English name: Pyridine sulfur trioxide English synonyms: Pyridine, compd.withsulfurtrioxide (1:1); Salfurtrioxidepyri-dinecomplex; Sulfurtrioxide,compd.withpyridine(1:1); (DIMETHYLAMINOMETHYL) STYRENE; VINYLBENZYLDIMETHYLAMINE; N,N-DIMETHYLVINYLBENZYLAMINE; POLY(4-VINYLPYRIDINE) SULFUR TRIOXID
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Appearance: White crystalline.Melting Point: 210 °C (subl.) (lit.)Flash point 198 °CStorage conditionsKeep in dark place,Inert atmosphere,Room temperatureMorphological crystalline powderColor: off-white to yellowish-beigePH 2.0 (100g/l, H2O, 20°C)Water solubility is easily soluble in water.Detection Method: HPLCBRN3684904InChIKeyXGAFCCUNHIMIRV-UHFFFAOYSA-NCAS DataBase Reference7379-35-3EPA Chemical Substance Information 4-Chloropyridine hydrochloride (7379-35-3)apply4-chloropyridine hydrochloride is an important intermediate in organic synthesis, which is widely used in the preparation of new
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2,3,4,5-TETRAFLUORBENZOYLCHLORID2,3,4,5-TETRAFLUOROBENZOYL CHLORIDEBenzoyl chloride, 2,3,4,5-tetrafluoro- (9CI)2,3,4,5-Tetrafluorobenzoyl2,3,4,5-Tetrafluorobenzoyl chloride 98%2,3,4,5-TETRAFLUOROBEZOYL CHLORIDE2,3,4,5-Tetrafluorobenzoylchloride98%94-24-62,3,4,5-Tetrafluorobenzoic acid chlorideBoiling point 65-66 °C 10mmDensity: 1.58 g/mL at 25 °C(lit.)Refractive index n20/D 1.4787(lit.)Flash point 194 °FSpecific gravity 1.580Sensitivity: Moisture sensitivityBRN5266860InChIKeyXWCKIXLTBNGIHV-UHFFFAOYSA-NCAS DataBase Reference94695-48-4
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S-3-Hydroxytetrahydrofuran [1]English name: S-3-hydroxytetrahydrofuranChinese aliases: (S)-(+)3-hydroxy-tetrahydrofuran; (S)-(+)-3-Hydroxytetrahydrofuran; (S)-3-Hydroxytetrahydrofuran;S-3-Hydroxytetrahydrofuran; Afatinib intermediatesSYNONYMS: (S)-(+)-3-HYDROXY TETAHYDRO FURAN; (S)-(-)-3-HYDROXY TETRAHYDRO FURAN; S-(+)-3-HYDROXYTETRAHYDROFURAN; (S)-3-Hydroxyterthydrofurane; S-(+)-3-Hydroxytetrahydofuran; (2S)-2-Hydroxy-1,4-epoxybutane; (3S)-3-Hydroxytetrahydrofuran; (2S)-1,4-Epoxy-2-hydroxybutane; Afatinib intermediatesCAS:86087-23-2Molecular formula: C4H8O2Molecular weight: 88.11Assay: 98%Pro
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1. Heparin was originally extracted from the liver, and is now mostly extracted from the intestinal mucosa of pigs, sheep, cattle and other animals, and can be extracted from the lungs and liver. Put the fresh intestinal mucosa into the reaction pot, add sodium chloride at 3%, and adjust the pH to 9.5 with 40% sodium hydroxide. Gradually heat up to 60-65 ° C within half an hour, continue to hold heat and stir for 2h, then heat up to 95 ° C, maintain for 10min, cool to below 50 ° C and filter.
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Appearance: Colorless liquid. The boiling point is 189 °C, the relative density is 1.073 (25/4 °C), the refractive index is 1.4494, and the flash point is 76 °C. Soluble in organic solvents, insoluble in water.Melting point -52 °cBoiling Point: 189 °C(lit.)Density 1.075 g/mL at 20 °CVapor pressure 4.2hPa at 25°CRefractive index n20/D 1.449(lit.)Flash point 169 °FStorage conditions RefrigeratorMorphological liquidThe color is transparentWater solubility: 0.5-1.0 g/100 mL at 20 ºCBRN2506Stability is unstable. Sensitivity to light. MEHQ of about 100 ppm can be used as a stabilizer.
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Clonazepam , with the system C15H10ClN3O3 , is a benzodiazepine tranquilizer. Clinically, it is commonly used for: (1) therapy of epilepsy and convulsions, which are advantageous for all kinds of epilepsy, in particular for small seizures and myoclonic seizures. Intravenous therapy of popularity epilepticus. (2) Treatment of anxiousness and insomnia. (3) It is additionally high quality for choreas.
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Basic informationChinese name: AtecaineChinese aliases: aceclofenac impurity H; Methyl 4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylate; [1]English name: Articaine;Methyl (4-methyl-3-(2-(propylamino)propionamido)-2-thiophencarboxylat); 3-(N-propyl-2-amino-propionylamino)-2-carbomethoxy-4-methylthiophene; 4-Methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylic acid,methyl ester; Articaina [INN-Spanish]; Carticaine;Aticaine compound is a white crystalline powder with the formula 4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylate.
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Experimental characteristicsLogP2.47600PSA55.98000Melting point 153-155°CDensity 1.215 Calculate the characteristicsExact molecular weight 198.07900Number of hydrogen bonded donors 1Number of hydrogen bond receptors 3Number of rotatable chemical bonds 2Number of heavy atoms 15Complexity 230Number of isotope atoms 0Determine the number of atomic stereoscopic centers 0The number of atomic stereoscopic centers is uncertain 0Determine the number of chemical bond stereotactic centers 0The number of chemical bond stereotactic centers is uncertain 0Number of covalent bond units 1Hydrophobi
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Basic informationChinese name: AtecaineChinese aliases: aceclofenac impurity H; Methyl 4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylate; [1]English name: Articaine;Methyl (4-methyl-3-(2-(propylamino)propionamido)-2-thiophencarboxylat); 3-(N-propyl-2-amino-propionylamino)-2-carbomethoxy-4-methylthiophene; 4-Methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylic acid,methyl ester; Articaina [INN-Spanish]; Carticaine;Aticaine compound is a white crystalline powder with the components 4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylate.
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Experimental characteristicsLogP 2.47600PSA 55.98000Melting factor 153-155°CDensity 1.215Calculate the characteristicsExact molecular weight 198.07900Number of hydrogen bonded donors 1Number of hydrogen bond receptors 3Number of rotatable chemical bonds 2Number of heavy atoms 15Complexity 230Number of isotope atoms 0Determine the range of atomic stereoscopic facilities 0The wide variety of atomic stereoscopic facilities is unsure 0Determine the quantity of chemical bond stereotactic facilities 0The wide variet
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Anilidine, also known as aminobenzene, is an organic compound, chemical formula C6H7N, is a colorless oily liquid, heated to 370 °C decomposition, slightly soluble in water, soluble in ethanol, ether and other organic solvents.Aniline is one of the most important amines. It is mainly used in the manufacture of dyes, drugs, resins, and can also be used as rubber vulcanization accelerators. It itself can also be used as a black dye.
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Quality standardsOff-white to light yellow crystalline appearanceContent 299% (HPLC)Melting point 216-220°C(s2C)Moisture S21.5%Ignition residue S0.2%The ethanol water dissolution test (thousand products) is qualifiedUses: used in pharmaceuticals, biological reagents, dyes, can also be used to synthesize 5,7-dimeryl flavonoids.As a medicine, resorcinol directly acts on the smooth muscle of the gastrointestinal tract and genitourinary tract, and is a prophilic non-atropine non-sinosynergine pure smooth muscle antispasmodic drug Compared with other smooth muscle spasmodics, resorcinol is characte
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Cyclohexanone is an natural compound with the components C6H10O , a saturated cyclic ketone with carbonyl carbon atoms blanketed in a six-membered ring. Colorless obvious liquid with earthy smell, with mint scent when containing hint quantities of phenol. Impurities are mild yellow, which enhance shade with the formation of impurities throughout storage time, and are water-white to gray-yellow, with a sturdy pungent odor.
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Trifluoroacetic acid, is an natural compound with the method C2HF3O2, on the whole used as a check reagent, solvent, catalyst and for natural synthesis.useMainly used as take a look at reagent, solvent, catalyst and for natural synthesis.First resource measuresSkin contact: Immediately cast off contaminated apparel and rinse with lots of strolling water for at least 15 minutes.
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Chinese name PiracetamForeign name PiracetamAlso known as 2-oxo-1-pyrrolidine acetamideChemical formula C6H10N2O2Molecular weight 142.156CAS 7491-74-9EINECS registration number 231-312-7Melting point 151 to 152 °CBoiling point 337.3 °cWater soluble and solubleDensity 1.239 g/cm³Appearance white crystalline powderFlash point 157.8 °cSecurity Description S26; S37/39Hazard symbol XiHazard description R36/37/38sourceThis product is 2-oxo-1-pyrrolidinyl acetamide, calculated as dry product, the C6H10N2O2 content should be 98.0% ~ 102.0%.CharactersThis product is white or off-white crystalline powde
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Boiling Point: 143-144 °C35 mm Hg(lit.)Density: 1.568 g/mL at 25 °C(lit.)Refractive index n20/D 1.572(lit.)Flash point > 230 °FSpecific gravity 1.568Sensitivity: Moisture sensitivityBRN4989077CAS DataBase Reference: 86393-34-2use2,4-Dichloro-5-fluorobenzoyl chloride is the main raw material for the preparation of third-generation quinolones such as trifluoroperidinol, trifluoroguabutenyl, pentafluridol and synthetic broad-spectrum antibiotics such as ciprofloxacin, and can also be used for pesticides, insecticides and ovicides, as well as the identification of plastics and resins.synthesisA
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Pharmacology and toxicologyThis product is an amide local anesthetic. After blood absorption or intravenous administration, it has obvious excitation and inhibition biphasic effect on the central nervous system, and there can be no precursor excitement, when the blood concentration is low, analgesia and drowsiness, and the pain threshold is increased; With the increase of dose, the effect or toxicity increases, and there is an anticonvulsant effect at the concentration of subtoxic blood drugs; When the blood concentration exceeds 5 mg·mL-1, convulsions can occur.
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Method 1Its preparation methods are as follows:2,4-disulfophenol alkali melt hydrolysis method;o-chlorophenol hydrolysis;phenol direct oxidation;phenolic oxidation;O-hydroxycyclohexanone dehydroaromatization.Among them, (1) and (2) the process is complex, the three wastes are polluted, and they are gradually replaced by new processes, while methods (4) and methods (5) are being industrialized abroad.
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