Chinese Name: 2-[(6-chloro-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidine]methyl]butyronitrileEnglish title 2-((6-Chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrileChinese alias alogliptin-B | 2-[(6-Chloro-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl]benzonitrile | Alogliptin intermediate | Alogliptin benzoate intermediate 1English aliases morePhysicochemical propertiesDensity 1.4±0.1 g/cm3boiling factor 418.0±55.0 °C at 760 mmHgMolecular formulation C13H10ClN3O2Molecular Weight: 275.690flash factor 206.6±31.5 °CExact
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English alias(S)-Methyl 3-(7-bromo-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanoate1H-1,4-Benzodiazepine-3-propanoic acid, 7-bromo-2,3-dihydro-2-oxo-5-(2- pyridinyl)-, methyl ester, (3S)-(3S)-(7-BroMo-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionic acid Methyl esterMethyl 3-[(3S)-7-bromo-2-oxo-5-(2- pyridinyl)-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanoateCAS308242-23-1InchiInChI=1S/C18H16BrN3O3/c1-25-16(23)8-7-15-18(24)22-13-6-5-11(19)10-12(13)17(21-15)14-4-2-3-9-20-14/h2-6,9-10,15H,7-8H2,1H3,(H,22,24)/t15-/m0/s1InChIkeyPITXBYGUVDYTBQ-HNN
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Chinese alias-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-Methyl(R)-2-[[2,4-Dioxo-3-methyl-6-(3-amino-1-piperidinyl)-1,2,3,4-tetrahydro-1-pyrimidinyl]methyl]-4- Flubenzonitrile succinate succinate tragliptin 2 tropagliptin succinate succinate tradagliptin succinate 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluorobenzonitrile succinateEnglish aliasSYR111472 SuccinateSuccinic acid - 2-({6-[(3R)-3-amino-1-piperidinyl]-3-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimid
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Chinese Name: 2-[(6-chloro-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidine]methyl]butyronitrileEnglish name 2-((6-Chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrileChinese alias alogliptin-B | 2-[(6-Chloro-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl]benzonitrile | Alogliptin intermediate | Alogliptin benzoate intermediate 1English aliases more Physicochemical propertiesDensity 1.4±0.1 g/cm3boiling point 418.0±55.0 °C at 760 mmHgMolecular formula C13H10ClN3O2Molecular Weight: 275.690flash point 206.6±31.5 °CExact Mass 275.046143PSA67.79000LogP1.95Vapour
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Basic informationChinese name: AtecaineChinese aliases: aceclofenac impurity H; Methyl 4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylate; [1]English name: Articaine;Methyl (4-methyl-3-(2-(propylamino)propionamido)-2-thiophencarboxylat); 3-(N-propyl-2-amino-propionylamino)-2-carbomethoxy-4-methylthiophene; 4-Methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylic acid,methyl ester; Articaina [INN-Spanish]; Carticaine;Aticaine compound is a white crystalline powder with the formula 4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylate.
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Materialized propertiesDensity:1.52±0.1 g/cm3(Predicted)Boiling point:545.3±50.0 °C(Predicted)PSA:80.65000logP:2.52900Acidity coefficient (PKA):11.15±0.70(Predicted)English alias(S)-Methyl 3-(7-bromo-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanoate1H-1,4-Benzodiazepine-3-propanoic acid, 7-bromo-2,3-dihydro-2-oxo-5-(2- pyridinyl)-, methyl ester, (3S)-(3S)-(7-BroMo-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionic acid Methyl esterMethyl 3-[(3S)-7-bromo-2-oxo-5-(2- pyridinyl)-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanoateCAS308242-23-1InchiInC
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Basic informationChinese name: AtecaineChinese aliases: aceclofenac impurity H; Methyl 4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylate; [1]English name: Articaine;Methyl (4-methyl-3-(2-(propylamino)propionamido)-2-thiophencarboxylat); 3-(N-propyl-2-amino-propionylamino)-2-carbomethoxy-4-methylthiophene; 4-Methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylic acid,methyl ester; Articaina [INN-Spanish]; Carticaine;Aticaine compound is a white crystalline powder with the components 4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylate.
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Appearance: White crystalline.Melting Point: 210 °C (subl.) (lit.)Flash point 198 °CStorage conditionsKeep in dark place,Inert atmosphere,Room temperatureMorphological crystalline powderColor: off-white to yellowish-beigePH 2.0 (100g/l, H2O, 20°C)Water solubility is easily soluble in water.Detection Method: HPLCBRN3684904InChIKeyXGAFCCUNHIMIRV-UHFFFAOYSA-NCAS DataBase Reference7379-35-3EPA Chemical Substance Information 4-Chloropyridine hydrochloride (7379-35-3)apply4-chloropyridine hydrochloride is an important intermediate in organic synthesis, which is widely used in the preparation of new
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S-3-Hydroxytetrahydrofuran [1]English name: S-3-hydroxytetrahydrofuranChinese aliases: (S)-(+)3-hydroxy-tetrahydrofuran; (S)-(+)-3-Hydroxytetrahydrofuran; (S)-3-Hydroxytetrahydrofuran;S-3-Hydroxytetrahydrofuran; Afatinib intermediatesSYNONYMS: (S)-(+)-3-HYDROXY TETAHYDRO FURAN; (S)-(-)-3-HYDROXY TETRAHYDRO FURAN; S-(+)-3-HYDROXYTETRAHYDROFURAN; (S)-3-Hydroxyterthydrofurane; S-(+)-3-Hydroxytetrahydofuran; (2S)-2-Hydroxy-1,4-epoxybutane; (3S)-3-Hydroxytetrahydrofuran; (2S)-1,4-Epoxy-2-hydroxybutane; Afatinib intermediatesCAS:86087-23-2Molecular formula: C4H8O2Molecular weight: 88.11Assay: 98%Pro
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2-Amino-3-hydroxypyridine properties, uses and production processPhysical and chemical properties 2-Amino-3-hydroxypyridine is gray-white to brown powder at room temperature and pressure, and has a certain alkalineness. It is insoluble in water, but has good solubility in alcoholic organic solvents, and can also be soluble in dimethyl sulfoxide with strong polarity. The chemical reaction 2-amino-3-hydroxypyridine structure contains a pyridine ring unit, the active hydroxyl group and amino group structure, and has good chemical reaction activity.
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Brief introductionAE-active ester, chemical title 2-methoxyimino-2-(2-amino-4-thiazolyl)-(z)-thioacetic acid benzothiazole ester. Appearance: white or mild yellow crystalline powder, melting factor 128130 °C.
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apply4-chloropyridine hydrochloride is an important intermediate in organic synthesis, which is widely used in the preparation of new medicines, pesticides, dyes, etc.use4-Chloropyridine hydrochloride can be used as a pharmaceutical intermediate in the process of laboratory organic synthesis and chemical and pharmaceutical research and development, and pyridine base can be used to synthesize more than 50 drugs, including antitumor drugs, penicillin, vasodilators, nicotinate, inositol nicotinate, etc.preparationPyridine is used as the starting material, and 4-chloropyridine hydrochloride is syn
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Clonazepam , with the system C15H10ClN3O3 , is a benzodiazepine tranquilizer. Clinically, it is commonly used for: (1) therapy of epilepsy and convulsions, which are advantageous for all kinds of epilepsy, in particular for small seizures and myoclonic seizures. Intravenous therapy of popularity epilepticus. (2) Treatment of anxiousness and insomnia. (3) It is additionally high quality for choreas.
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2,3,4,5-TETRAFLUORBENZOYLCHLORID2,3,4,5-TETRAFLUOROBENZOYL CHLORIDEBenzoyl chloride, 2,3,4,5-tetrafluoro- (9CI)2,3,4,5-Tetrafluorobenzoyl2,3,4,5-Tetrafluorobenzoyl chloride 98%2,3,4,5-TETRAFLUOROBEZOYL CHLORIDE2,3,4,5-Tetrafluorobenzoylchloride98%94-24-62,3,4,5-Tetrafluorobenzoic acid chlorideBoiling point 65-66 °C 10mmDensity: 1.58 g/mL at 25 °C(lit.)Refractive index n20/D 1.4787(lit.)Flash point 194 °FSpecific gravity 1.580Sensitivity: Moisture sensitivityBRN5266860InChIKeyXWCKIXLTBNGIHV-UHFFFAOYSA-NCAS DataBase Reference94695-48-4
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Chinese name: 1-[[2-(4-chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride Chinese synonymous with green casserin intermediate; Lorcaserin intermediate 2; Lorcaserin Impurity B; 1-[[2-(4-chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride; Lorcaserin hydrochloride intermediate 2; 2-Chloro-N-(4-chlorophenethyl)propan-1-amine chloride; Lorcaserin impurity B (EP); Chlorocasein Impurity B English name 1-[[2-(4-Chlorophenyl)ethyl]amino]-2-chloropropane English synonym 1-[[2-(4-Chlorophenyl)ethyl]amino]-2-chloropropane; 1-[[2-(4-Chlorophenyl)ethyl]amino]-2-chloropropaneHydrochloride; Benzene
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CAS:86087-23-2S-3-Hydroxytetrahydrofuran [1]English name: S-3-hydroxytetrahydrofuranChinese aliases: (S)-(+)3-hydroxy-tetrahydrofuran; (S)-(+)-3-Hydroxytetrahydrofuran; (S)-3-Hydroxytetrahydrofuran;S-3-Hydroxytetrahydrofuran; Afatinib intermediatesSYNONYMS: (S)-(+)-3-HYDROXY TETAHYDRO FURAN; (S)-(-)-3-HYDROXY TETRAHYDRO FURAN; S-(+)-3-HYDROXYTETRAHYDROFURAN; (S)-3-Hydroxyterthydrofurane; S-(+)-3-Hydroxytetrahydofuran; (2S)-2-Hydroxy-1,4-epoxybutane; (3S)-3-Hydroxytetrahydrofuran; (2S)-1,4-Epoxy-2-hydroxybutane; Afatinib intermediatesCAS:86087-23-2Molecular formula: C4H8O2Molecular weight: 88.1
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Chinese identify thiopronin Chinese synonymous N-(2-mercaptopropionyl)-glycine; Thiopron; Tiopronin; N-(2-Mercaptopropionyl)glycine; mercaptopropionylglycine; Thiopronin impurities; (±)-N-(2-mercapto-1-oxopropyl)glycine; TIOPRONIN English identify Tiopronin English synonym A-MERCAPTOPROPIONYL GLYCINE; ALPHA-MERCAPTO PROPIONYL GLYCINE; LABOTEST-BB LT00451995; TIOPRONIN; N-(2-MERCAPTOPROPIONYL)GLYCINE; TOPRONIN; (2-Mercaptopropionamido)acetic acid; (2-Mercaptopropionyl)glycineCAS1953-02-2Molecular system C5H9NO3S molecular weight 163.19EINECS217-778-4 associate
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2-Amino-3-hydroxypyridine properties, makes use of and manufacturing processPhysical and chemical houses 2-Amino-3-hydroxypyridine is gray-white to brown powder at room temperature and pressure, and has a positive alkalineness. It is insoluble in water, however has excellent solubility in alcoholic natural solvents, and can additionally be soluble in dimethyl sulfoxide with robust polarity.
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Chinese name: 1-[[2-(4-chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride Chinese synonymous with inexperienced casserin intermediate; Lorcaserin intermediate 2; Lorcaserin Impurity B; 1-[[2-(4-chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride; Lorcaserin hydrochloride intermediate 2; 2-Chloro-N-(4-chlorophenethyl)propan-1-amine chloride; Lorcaserin impurity B (EP); Chlorocasein Impurity B English title 1-[[2-(4-Chlorophenyl)ethyl]amino]-2-chloropropane English synonym 1-[[2-(4-Chlorophenyl)ethyl]amino]-2-chloropropane; 1-[[2-(4-Chlorophenyl)ethyl]amino]-2-chloro
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Appearance: Light yellow crystalline powderMelting Point: 128-130 °C(lit.)Boiling Point:563.2±42.0 °C(Predicted)Density 1.63refractive index1.6200 (estimate)Storage conditions: Refrigerator, Under Inert AtmosphereSolubility soluble in chloroform (a little), methanol (a little)pKa1.22±0.10(Predicted)Morphological solidsThe color is pale yellowStability: Moisture sensitiveInChIKeyCOFDRZLHVALCDU-YVLHZVERSA-NCAS DataBase Reference80756-85-0Brief introductionAE-active ester, chemical name 2-methoxyimino-2-(2-amino-4-thiazolyl)-(z)-thioacetic acid benzothiazole ester.
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CAS:26412-87-3Chinese Name: Thiopidine trioxide Chinese synonyms: compounds of thiopidine trioxide; sulfur trioxide-pyridine complex; Pyridine sulfur trioxide; Thiopidine trioxide; Thiopidine trioxide complex; Synthesis of thiophorine trioxide; Sulfur trioxide yridine complex; Sulfurtrioxypyridine complicated [2]English name: Pyridine sulfur trioxide English synonyms: Pyridine, compd.withsulfurtrioxide (1:1); Salfurtrioxidepyri-dinecomplex; Sulfurtrioxide,compd.withpyridine(1:1); (DIMETHYLAMINOMETHYL) STYRENE; VINYLBENZYLDIMETHYLAMINE; N,N-DIMETHYLVINYLBENZYLAMINE; POLY(4-V
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Appearance: Colorless liquid. The boiling point is 189 °C, the relative density is 1.073 (25/4 °C), the refractive index is 1.4494, and the flash point is 76 °C. Soluble in organic solvents, insoluble in water.Melting point -52 °cBoiling Point: 189 °C(lit.)Density 1.075 g/mL at 20 °CVapor pressure 4.2hPa at 25°CRefractive index n20/D 1.449(lit.)Flash point 169 °FStorage conditions RefrigeratorMorphological liquidThe color is transparentWater solubility: 0.5-1.0 g/100 mL at 20 ºCBRN2506Stability is unstable. Sensitivity to light. MEHQ of about 100 ppm can be used as a stabilizer.
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CAS1563-56-0InchiInChI=1S/C12H9BrN2O/c13-8-4-5-10(14)9(7-8)12(16)11-3-1-2-6-15-11/h1-7H,14H2InChIkeyKHVZPFKJBLTYCC-UHFFFAOYSA-NChinese aliasBromazepam Impurity A Bromazepam Impurity A(EP) Standard 2-Amino-5-bromophenyl-2-pyridylmethanone 2-(2-amino-5-bromobenzoyl)pyridineCanonical SmilesC1=CC=NC(=C1)C(=O)C2=C(C=CC(=C2)Br)NInternationalization joint naming(2-amino-5-bromophenyl)-pyridin-2-ylmethanoneEnglish alias2-(5-Bromo-2-aminobenzoyl)pyridine(2-Amino-5-bromophenyl)-2-pyridinylmethanone2-(2-Amino-5-bromobenzoyl)pyridineKetone, 2-amino-5-bromophenyl 2-pyridyl2-Amino-5-bromophenyl-2-pyridylmet
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Method 1Its preparation methods are as follows:2,4-disulfophenol alkali melt hydrolysis method;o-chlorophenol hydrolysis;phenol direct oxidation;phenolic oxidation;O-hydroxycyclohexanone dehydroaromatization.Among them, (1) and (2) the process is complex, the three wastes are polluted, and they are gradually replaced by new processes, while methods (4) and methods (5) are being industrialized abroad.
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